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desvenlafaxine will boost the stage or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, four hundred mg) lessen the CYP2D6 substrate dose by up to 50%; no dosage adjustment required with desvenlafaxine doses seven consecutive time